Peptide Profiles
What Is Orexin B? The Selective Half of the Pair
Orexin B is a 28-residue peptide from the same precursor as orexin A, but it prefers OX2R and has no disulfide bridges. The structural reasons.
Neuropeptides
Signalling peptides that act in the central nervous system. These articles cover receptor targets and selectivity, the blood-brain-barrier question that determines whether a peripheral result means anything centrally, the short half-lives typical of this class, and the behavioural and electrophysiological readouts the published studies rely on.
Peptide Profiles
What Is VIP? Receptors, Selectivity and Stability
VIP is a 28-residue peptide acting at VPAC1 and VPAC2. Why selectivity between them is hard, and what the structural work has resolved.
Research Reviews
KPV Research: What the Melanocortin Literature Shows
A review of KPV research: the alpha-MSH fragment, murine colitis models, keratinocyte work, and why delivery rather than the peptide is the focus.
Peptide Profiles
What Is Orexin A? Structure, Receptors and Literature
Orexin A is a 33-residue peptide with two disulfide bridges, acting at OX1R and OX2R. Its discovery, receptor pharmacology and analytical literature.
Peptide Profiles
What Is Oxytocin? Structure, Receptor and Stability
Oxytocin is a nine-residue cyclic neuropeptide with a disulfide bridge. Its receptor, its notorious solution instability and the published chemistry.
Peptide Profiles
What Is DSIP? A Peptide With an Unresolved Mechanism
DSIP is a nine-residue peptide isolated in the 1970s whose mechanism remains unestablished. What the literature actually says, and what it does not.