Comparisons
Mazdutide and Survodutide vs Retatrutide: Dual vs Triple
Mazdutide and survodutide are GLP-1/glucagon dual agonists; retatrutide adds the GIP receptor. Structures, phase 2 and 3 endpoints, and what the gap implies.
Comparisons
Mazdutide and survodutide are GLP-1/glucagon dual agonists; retatrutide adds the GIP receptor. Structures, phase 2 and 3 endpoints, and what the gap implies.
Peptide Profiles
Mazdutide (IBI362, LY3305677) is a GLP-1 and glucagon receptor dual agonist built on an oxyntomodulin scaffold. Its trials and lab handling.
Comparisons
Two of these three engage the glucagon receptor and one engages GIP instead. The receptor split, the trial records and what it means in the lab.