Comparisons
MK-677 vs Sermorelin: Ghrelin Mimetic or GHRH Analogue
MK-677 is an oral non-peptide ghrelin-receptor agonist; sermorelin is a GHRH peptide fragment. Receptors, second messengers and trial evidence compared.
Neuroendocrine research
Hypothalamic and pituitary signalling outside the growth hormone axis, including the reproductive and stress axes. These articles cover the receptors involved and where they sit in a chain, why several of these systems read the frequency of a signal rather than its amount, and what that means for an experiment: a readout two steps downstream of a stimulus is ambiguous about which step responded.
Research Reviews
How Does Sermorelin Work? The GHRH Receptor Pathway
Sermorelin is GHRH(1-29)-NH2. It binds the pituitary GHRH receptor, raises cAMP and leaves pulse timing to somatostatin. The pathway, step by step.
Comparisons
Gonadorelin vs hCG: Two Points on the Same Axis
Gonadorelin acts at the GnRH receptor on the pituitary; hCG acts at the LH receptor on the gonad. Different molecules, different levels of one axis.
Peptide Profiles
How Does Kisspeptin Work? The KNDy Pulse Generator
Kisspeptin acts on KNDy neurons upstream of GnRH, where it helps generate the pulses that drive the axis. The receptor, the circuit, the evidence.
Peptide Profiles
What Is Gonadorelin? GnRH Structure and Pulsatility
Gonadorelin is synthetic GnRH, a decapeptide whose defining feature is pulsatile signalling. Its structure, receptor behaviour and research literature.
Peptide Profiles
What Is Kisspeptin-10? KISS1R Ligand Profile
Kisspeptin-10 is the C-terminal decapeptide of kisspeptin, the ligand for KISS1R. A profile of the receptor biology and the KNDy neuron literature.