Research Reviews
5-Amino-1MQ Structure, CAS and Mechanism of Action
5-Amino-1MQ is a permanently charged quinolinium cation that inhibits NNMT. Why the charge, the salt form and the CAS number all matter.
Metabolic research
Published work on energy balance, glucose handling, lipid metabolism and the receptors involved. Each result is reported with the species and model it came from, because a rodent metabolic result and a human pharmacokinetic result are not interchangeable evidence.
Lab Handling
AOD-9604 Reconstitution and Half-Life: What Is Known
How to reconstitute 5 mg and 10 mg AOD-9604 vials, why its disulfide bond changes handling, and what the published metabolite work says about its half-life.
Comparisons
AOD-9604 Compared: Tesamorelin, Incretins, Secretagogues
AOD-9604 is an hGH fragment studied for lipolysis. How it differs from tesamorelin, sermorelin, CJC-1295, ipamorelin, MOTS-c and incretins.
Comparisons
Cagrilintide With Retatrutide or Tirzepatide
Cagrilintide acts on amylin and calcitonin receptors, not incretin receptors. Why it is paired with GLP-1 agonists, what CagriSema showed, and blend handling.
Comparisons
Mazdutide and Survodutide vs Retatrutide: Dual vs Triple
Mazdutide and survodutide are GLP-1/glucagon dual agonists; retatrutide adds the GIP receptor. Structures, phase 2 and 3 endpoints, and what the gap implies.
Comparisons
Tesamorelin vs Retatrutide, Tirzepatide and MOTS-c
Tesamorelin works through the GH axis; incretin peptides through GIP, GLP-1 and glucagon receptors; MOTS-c through AMPK. Four different mechanisms compared.
Research Reviews
Tirzepatide Half-Life: About Five Days, and Why
Tirzepatide's half-life is about 5 days, from a population PK model of 19 pooled studies. How albumin binding produces it and what it means for study design.
Peptide Profiles
How Does SLU-PP-332 Work? ERR Agonism Explained
SLU-PP-332 activates the estrogen-related receptors, nuclear receptors that act on gene transcription. Why that makes the timescale hours, not minutes.
Research Reviews
5-Amino-1MQ Human Trials: What Actually Exists
Searches for 5-Amino-1MQ human trials return nothing in PubMed. The evidence is preclinical NNMT inhibition, and the gaps are worth naming.
Peptide Profiles
What Is SLU-PP-332? The ERR Agonist Explained
SLU-PP-332 is a synthetic pan-agonist of the estrogen-related receptors ERRa, ERRb and ERRg, studied in rodents as a tool for probing oxidative metabolism.
Peptide Profiles
What Is AICAR? AMPK Activator Profile
AICAR is a nucleoside that cells convert to ZMP, an AMP analogue that activates AMPK. A profile of the mechanism and its interpretive limits.
Peptide Profiles
What Is MOTS-c? The Mitochondria-Encoded Peptide
MOTS-c is a 16-amino-acid peptide encoded in mitochondrial 12S rRNA. Its discovery, AMPK and folate-cycle mechanism, exercise and ageing research, and handling.