Lab Handling
AOD-9604 Reconstitution and Half-Life: What Is Known
How to reconstitute 5 mg and 10 mg AOD-9604 vials, why its disulfide bond changes handling, and what the published metabolite work says about its half-life.
BEHIND THE ARTICLES
Jesse Brooks
Areas of expertise: Peptide lead discovery & screening, structural modification & stability optimization, pharmacodynamics & mechanism of action
Published articles
Testing & Quality
BPC-157 Purity Testing: How to Read a Certificate
What HPLC purity, mass spectrometry and third-party testing actually tell you about a BPC-157 lot, what they miss, and how to read a certificate of analysis.
Lab Handling
TB-500 Reconstitution: Method, Concentrations, Storage
How to reconstitute TB-500, concentration and molar tables for 5 and 10 mg vials, why its sequence is forgiving, and what to verify before you start.
Research Reviews
TB-500 Half-Life and Mechanism: What Is Documented
No formal half-life study exists for TB-500's heptapeptide. What metabolite work shows, how the actin-binding region is thought to act, and how to read claims.
Comparisons
Sermorelin vs Ipamorelin vs Tesamorelin: Three Routes to GH
Sermorelin, tesamorelin and CJC-1295 act on the GHRH receptor; ipamorelin and MK-677 on the ghrelin receptor. How the two classes differ and compare.
Comparisons
Semax Compared: Adamax, Cerebrolysin and NAD+
Semax is a defined heptapeptide; Cerebrolysin is a mixture, NAD+ a coenzyme, Adamax a marketed variant. Why these are not like-for-like comparisons.
Peptide Profiles
Selank Semax Blend: Two Heptapeptides in One Vial
What a Semax and Selank blend contains, why the two are paired, how to calculate each component, and why 62 Da makes identity testing straightforward.
Testing & Quality
What ‘Research Use Only’ Means for Peptides
Research use only is a statement about regulatory status, not quality. What it means, how RUO material differs from a medicine, and what a COA can establish.
Comparisons
NAD+ vs MOTS-c: Coenzyme and Mitochondrial Peptide
NAD+ is a nucleotide coenzyme; MOTS-c a 16-residue peptide encoded in mitochondrial DNA. Both connect to mitochondria, but through quite different routes.
Comparisons
Mazdutide and Survodutide vs Retatrutide: Dual vs Triple
Mazdutide and survodutide are GLP-1/glucagon dual agonists; retatrutide adds the GIP receptor. Structures, phase 2 and 3 endpoints, and what the gap implies.
Testing & Quality
How Are Peptides Made? Solid-Phase Synthesis Explained
Research peptides are built one residue at a time on a solid resin, then cleaved, purified by HPLC and freeze-dried. Each step explains part of the COA.
Comparisons
GLOW Blend vs GHK-Cu Alone: What the Other Two Add
GLOW is GHK-Cu 50 mg plus TB-500 10 mg and BPC-157 10 mg. What the extra components contribute, how the maths differs, and when the single peptide is better.