Peptide Profiles
What Is B7-33? A Single-Chain Relaxin Mimetic
B7-33 is a single-chain peptide derived from the relaxin-2 B chain, reported as a functionally selective RXFP1 agonist. The published evidence.
BEHIND THE ARTICLES
Jesse Brooks
Areas of expertise: Peptide lead discovery & screening, structural modification & stability optimization, pharmacodynamics & mechanism of action
Published articles
Testing & Quality
How to Verify Sermorelin Identity From Its Data
Sermorelin is a 29-residue fragment that is easy to misidentify. The checks that distinguish it from its analogues using certificate data alone.
Lab Handling
SLU-PP-332 Handling: Solubility, Purity and Storage
SLU-PP-332 is a small molecule, not a peptide, so it needs different handling. Co-solvents, precipitation checks and what its purity data should show.
Lab Handling
Sermorelin Reconstitution, Half-Life and Storage
Sermorelin is GHRH(1-29), a 29-residue peptide with a short measured half-life. Reconstitution maths, stability chemistry and storage practice.
Comparisons
NAD vs NR: Precursor Chemistry and the Evidence
Nicotinamide riboside is a precursor; NAD+ is the cofactor itself. What the comparison literature reports, and where the evidence is thin.
Comparisons
NAD+ to NADH: Reduction or Oxidation?
NAD+ to NADH is a reduction. Why the plus sign is not a charge on the whole molecule, and why the ratio matters more than either concentration.
Comparisons
SLU-PP-332 vs MOTS-c vs 5-Amino-1MQ Compared
Three metabolic research compounds with three different mechanisms: a nuclear receptor agonist, a mitochondrial peptide and an enzyme inhibitor.
Comparisons
KPV vs BPC-157: Two Different Research Lineages
KPV is a melanocortin-derived tripeptide; BPC-157 is a 15-residue gastric peptide fragment. Their literatures barely overlap, and the reason matters.
Lab Handling
IGF-1 LR3 Reconstitution: It Is a Protein, Not a Peptide
IGF-1 LR3 is an 83-residue folded protein with three disulfide bridges. Why peptide reconstitution practice does not transfer, and what does.
Comparisons
IGF-1 DES vs LR3: Two Ways to Evade Binding Proteins
IGF-1 DES and LR3 both alter the N-terminus to reduce binding protein capture, but by opposite means: one removes residues, one adds them.
Comparisons
HGH Fragment 176-191 vs AOD-9604: Are They the Same?
HGH Fragment 176-191 and AOD-9604 are related but not identical: one carries an added N-terminal tyrosine. What the published work actually covers.
Comparisons
Hexarelin vs Ipamorelin: Selectivity and Structure
Hexarelin and ipamorelin are both secretagogues, but one was designed for selectivity. A structural and pharmacological comparison of the two.