Research Reviews
SS-31 Kidney Research: Where the Literature Concentrates
The renal literature is the densest part of SS-31 research, spanning cisplatin injury, diabetic nephropathy and ageing glomeruli. A review.
BEHIND THE ARTICLES
Jesse Brooks
Areas of expertise: Peptide lead discovery & screening, structural modification & stability optimization, pharmacodynamics & mechanism of action
Published articles
Comparisons
Sermorelin vs HGH: Secretagogue or Direct Replacement
Sermorelin stimulates an axis; somatropin replaces its product. The difference in pulsatility, feedback and regulatory status, for research context.
Comparisons
Semax vs Bromantane: Peptide and Small Molecule
Semax is a peptide with a modern literature; bromantane is an adamantane small molecule documented largely in 1990s Russian-language journals.
Lab Handling
Selank Storage and Stability in the Laboratory
Selank is a tuftsin analogue extended with a Pro-Gly-Pro tail. What that design does for stability, and how the peptide should be stored.
Testing & Quality
Peptide Counterions: TFA vs Acetate and Why It Matters
Every basic peptide arrives as a salt. Why trifluoroacetate is the default, what exchange achieves, and how the counterion distorts concentration.
Comparisons
MOTS-c vs Retatrutide: Mitochondrial vs Receptor
MOTS-c is a mitochondrially encoded peptide with no established receptor; retatrutide is a triple incretin receptor agonist. Two different sciences.
Research Reviews
KPV Research: What the Melanocortin Literature Shows
A review of KPV research: the alpha-MSH fragment, murine colitis models, keratinocyte work, and why delivery rather than the peptide is the focus.
Research Reviews
Kisspeptin-10 Half-Life and Its Decomposition Product
A 2013 LC-MS/MS study measured kisspeptin-10 pharmacokinetics in rats and characterised its decomposition product. What that means for handling.
Comparisons
Is NAD+ a Peptide or a Coenzyme?
NAD+ is a dinucleotide coenzyme, not a peptide. Why it appears in peptide catalogues anyway, and what that means for how it is handled.
Comparisons
IGF-1 LR3 vs Sermorelin: Downstream Versus Upstream
Sermorelin acts at the top of the GH-IGF axis; IGF-1 LR3 is a modified version of the axis output. A comparison of upstream and downstream tools.
Research Reviews
IGF-1 LR3 Half-Life and What Receptor Grade Means
IGF-1 LR3's persistence comes from evading binding proteins, not from intrinsic stability. What the clearance literature shows and what grade labels mean.
Comparisons
GHRP vs GHRH Analogues: Two Receptors, Not One
Hexarelin and GHRP-2 act at the ghrelin receptor; sermorelin and tesamorelin at the GHRH receptor. Why the two families are not interchangeable.