Peptide Profiles
What Is Mazdutide? An Oxyntomodulin-Based Dual Agonist
Mazdutide (IBI362, LY3305677) is a GLP-1 and glucagon receptor dual agonist built on an oxyntomodulin scaffold. Its trials and lab handling.
BEHIND THE ARTICLES
Jesse Brooks
Areas of expertise: Peptide lead discovery & screening, structural modification & stability optimization, pharmacodynamics & mechanism of action
Published articles
Comparisons
SS-31 vs MOTS-c: Targeting Mitochondria Two Ways
SS-31 accumulates in mitochondria and binds cardiolipin; MOTS-c is encoded by mitochondrial DNA. Opposite relationships to the same organelle.
Comparisons
Orforglipron vs Tirzepatide: Pill Versus Peptide
Orforglipron is a non-peptide taken by mouth; tirzepatide is an injected dual-receptor peptide with a measured 5-day half-life. A full comparison.
Comparisons
Mazdutide vs Survodutide vs Tirzepatide Compared
Two of these three engage the glucagon receptor and one engages GIP instead. The receptor split, the trial records and what it means in the lab.
Lab Handling
Kisspeptin-10 Reconstitution and Working Solutions
Kisspeptin-10 has a characterised decomposition product and short measured exposure. How to reconstitute it so the concentration is what you think.
Peptide Profiles
How Does SLU-PP-332 Work? ERR Agonism Explained
SLU-PP-332 activates the estrogen-related receptors, nuclear receptors that act on gene transcription. Why that makes the timescale hours, not minutes.
Peptide Profiles
How Does Kisspeptin Work? The KNDy Pulse Generator
Kisspeptin acts on KNDy neurons upstream of GnRH, where it helps generate the pulses that drive the axis. The receptor, the circuit, the evidence.
Comparisons
Gonadorelin vs Kisspeptin: Two Steps on One Axis
Kisspeptin acts on the neurons that generate the pulse; gonadorelin is the pulse itself. Where each enters the axis and what that changes.
Comparisons
Epithalon vs Thymalin: Tetrapeptide or Preparation
Epithalon is a defined four-residue peptide; thymalin is a thymic peptide preparation. Same research tradition, very different levels of definition.
Peptide Profiles
What Is Orexin B? The Selective Half of the Pair
Orexin B is a 28-residue peptide from the same precursor as orexin A, but it prefers OX2R and has no disulfide bridges. The structural reasons.
Comparisons
Thymalin vs Thymulin: Two Different Compounds
Thymalin is a Russian thymic peptide preparation; thymulin is a defined zinc-dependent nonapeptide. Similar names, unrelated chemistry.
Comparisons
SLU-PP-915 vs SLU-PP-332: What Changed, and Why
SLU-PP-915 came out of a chemistry programme to improve on SLU-PP-332. A 2026 paper characterises both analytically, including metabolism.